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目的探讨HIF-2α、VEGF蛋白在胎盘中的表达与子痫前期发病的关系。方法应用免疫组化方法检测30例正常妊娠组,25例轻度子痫前期组及35例重度子痫前期组HIF-2α、VEGF蛋白表达。结果 HIF-2α、VEGF蛋白在正常妊娠组的表达低于子痫前期组,差异有显著性,两者在重度子痫前期组与轻度子痫前期组的表达差异无显著性(P>0.05)。结论 HIF2α、VEGF可能参与子痫前期的发病过程。
Objective To investigate the relationship between the expression of HIF-2α and VEGF in the placenta and the pathogenesis of preeclampsia. Methods Immunohistochemistry was used to detect the expression of HIF-2α and VEGF in 30 normal pregnant women, 25 mild preeclampsia patients and 35 severe preeclampsia patients. Results The expression of HIF-2α and VEGF protein in normal pregnancy group was lower than that in preeclampsia group, the difference was significant, there was no significant difference between the two groups in severe preeclampsia group and mild preeclampsia group (P> 0.05 ). Conclusions HIF2α and VEGF may be involved in the pathogenesis of preeclampsia.