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目的 :利用条件性位置偏爱实验研究中药成分青藤碱对小鼠吗啡奖赏效应的影响。方法 :实验采用有倾向性程序。吗啡 (9mg· kg-1,sc,每日 1次 ,5 d)引起小鼠显著的位置偏爱效应。在训练阶段每天 sc吗啡前3 0 min预先给予青藤碱 (1 0 ,3 0和 60 mg· kg-1,ip)可剂量依赖性地抑制吗啡引起的小鼠位置偏爱效应。结果 :提示预先给予青藤碱能消除吗啡产生的条件性位置偏爱。
Objective : To study the effect of sinomenine, a component of traditional Chinese medicine, on the morphine reward effect in mice by using conditional location preference test. Methods : The experiment used a prone procedure. Morphine (9 mg·kg-1, sc, once daily, 5 d) caused significant position preference in mice. Sinusine (10, 30, and 60 mg·kg-1, ip) was pre-administered 30 min before sc morphine every day during the training phase in a dose-dependent manner to inhibit the morphine-induced position preference effect in mice. Results: It was suggested that pre-administration of sinomenine could eliminate the conditional preference of morphine production.