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我们用离体豚鼠右心房乳头肌标本,同 时观察了碘化二甲基木防己碱(Dimethylfrliobine ioelicle DMT)对心肌电活动和收缩力的影响。以探讨DMT对心肌的直接作用。用时还用麻醉犬进行血液动力学指标的观察,为临床用药提供较全面的科学实验依据。 实验用两个浓度(0.025和0.25mM)。给药前记录各指标作为对照,每次给药后观察20分钟。实验结果说明,低浓度DMT对心肌收缩力几无作用,而高浓度时可明显增加心肌收缩力。从对照8+7ng(X±SE,
We used isolated guinea pig right atrial papillary muscle specimens and observed the effects of Dimethylfrliobine ioelicle (DMT) on myocardial electrical activity and contractility. To investigate the direct effect of DMT on the myocardium. When used, anesthetized dogs were also used to observe the hemodynamic parameters, providing a more comprehensive scientific experimental basis for clinical use. Experiments used two concentrations (0.025 and 0.25 mM). Before administration, each index was recorded as a control, and observed 20 minutes after each administration. The experimental results show that low concentrations of DMT have little effect on myocardial contractility, but at high concentrations can significantly increase myocardial contractility. From control 8+7ng (X±SE,