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目的观察中西医结合方法治疗糖尿病肾病的临床疗效。方法选取2014年1月-2015年9月医院收治的糖尿病肾病患者116例,所有患者随机分为治疗组和对照组各58例,对照组给予西医常规治疗(糖尿病肾病饮食,控制血糖、降压、调节血脂治疗),治疗组在西医常规治疗基础上应用益肾活血中药汤剂。观察2组患者临床治疗效果,比较2组治疗前后空腹血糖(FBG)、餐后2h血糖(2h BG)、尿微量蛋白(UAER)、24h尿蛋白定量(U-pro)变化情况。结果治疗组总有效率为91.38%高于对照组的77.59%,差异有统计学意义(P<0.01)。治疗2个疗程8周后,2组患者的FBG、2hBG、UAER、U-pro均明显下降,与治疗前比较差异有统计学意义(P<0.05和P<0.01);且治疗组下降幅度较对照组大,差异有统计学意义(P<0.05)。结论中西医结合方法治疗糖尿病肾病临床疗效显著,优于单纯西医疗法,值得临床推广。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of diabetic nephropathy. Methods A total of 116 patients with diabetic nephropathy admitted from January 2014 to September 2015 in our hospital were enrolled. All patients were randomly divided into treatment group (58 cases) and control group (58 cases). The control group was given conventional western medicine (diet of diabetic nephropathy, blood glucose control, , Regulation of blood lipids treatment), the treatment group on the basis of conventional Western medicine Yishenhuoxue Decoction. The clinical effects of two groups were observed. The fasting blood glucose (FBG), 2h postprandial blood glucose (2h BG), urinary microalbuminuria (UAER) and urinary protein excretion (U-pro) were compared between the two groups before and after treatment. Results The total effective rate of the treatment group was 91.38% higher than that of the control group (77.59%), the difference was statistically significant (P <0.01). After treatment of two courses for 8 weeks, the FBG, 2hBG, UAER and U-pro in two groups were significantly decreased compared with those before treatment (P <0.05 and P <0.01) The control group, the difference was statistically significant (P <0.05). Conclusion The combination of traditional Chinese and Western medicine treatment of diabetic nephropathy clinical efficacy was significantly better than the simple Western medical treatment, is worth clinical promotion.