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目的：评价压宁定预防气管插管时心血管反应的效果。方法：选择３０例择期手术的全麻病人，随机分Ａ组（对照）、Ｂ组（０２ｍｇ／ｋｇ压宁定）和Ｃ组（０４ｍｇ／ｋｇ压宁定）各１０例。全麻诱导均静注硫喷妥钠５０ｍｇ／ｋｇ，芬太尼３０ｍｇ／ｋｇ，琥珀胆碱１５ｍｇ／ｋｇ。压宁定Ｂ和Ｃ组诱导前５ｍｉｎ先静注压宁定。结果：气管插管期间三组血压较诱导前均增高，Ａ组升高显著（Ｐ＜００１），Ｂ、Ｃ组升高无统计学意义（Ｐ＞００５），心率及心率收缩压乘积Ａ、Ｃ组较诱导前升高显著（Ｐ＜００１或＜００５），Ｂ组变化较小（Ｐ＜００５）。结论：压宁定对预防气管插管心血管反应有效，但不能完全消除该反应，且随着剂量的增加可反射性地增加插管期间的心率。
OBJECTIVE: To evaluate the efficacy of nifedipine in preventing cardiovascular reactions during tracheal intubation. Methods: A total of 30 patients undergoing elective surgery were randomly divided into group A (control), group B (0.2 mg / kg ningdin) and group C (0 4 mg / kg ningedin) respectively. Induction of anesthesia were intravenous thiopental 5 0mg / kg, fentanyl 3 0mg / kg, succinylcholine 1 5mg / kg. Prescriptions of B and C were given intravenously before 5 minutes of induction. Results: During the intubation period, the blood pressure of the three groups increased significantly compared with that before induction. The blood pressure of group A increased significantly (P <001), but there was no significant difference between group B and C (P> 005) Compression product A, C group than before induction increased significantly (P <0 01 or <0 05), B group smaller changes (P <0 05). Conclusion: PRD is effective in preventing tracheal intubation and cardiovascular response, but it can not completely eliminate the reaction, and reflexively increases the heart rate during intubation as the dose increases.