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目的:探讨两种治疗方案对儿童哮喘急性发作的治疗效果。方法:2010年2月至2011年2月我院确诊的哮喘急性发作患儿72例,随机分为治疗组和对照组各36例。治疗组给予复方异丙托溴铵加布地奈德混悬液联合雾化吸入治疗,对照组采用沙丁胺醇溶液加地塞米松联合雾化吸入治疗,观察并记录临床症状、体征(咳嗽、憋喘、肺部哮鸣音)及肺功能改善情况。结果:治疗组总有效率为97.0%,对照组总有效率78.0%,两组比较差异有统计学意义(χ2=6.291,P<0.05)。两组患儿治疗后峰值呼气流速(PEF)比较差异有统计学意义(P<0.01)。结论:复方异丙托溴铵联合布地奈德治疗儿童哮喘急性发作效果显著,给药方法简单、方便,价廉,患儿依从性好,值得临床推广应用。
Objective: To investigate the therapeutic effects of two treatment regimens on acute asthma in children. Methods: From February 2010 to February 2011, 72 children with acute asthma in our hospital were randomly divided into treatment group (36 cases) and control group (36 cases). The treatment group was given ipratropium bromide plus budesonide suspension combined with inhalation therapy, the control group was treated with salbutamol plus dexamethasone inhalation therapy, observation and record of clinical symptoms and signs (cough, wheezing, lung Department of wheeze) and improve lung function. Results: The total effective rate was 97.0% in the treatment group and 78.0% in the control group. The difference between the two groups was statistically significant (χ2 = 6.291, P <0.05). The difference of peak expiratory flow (PEF) between the two groups was statistically significant (P <0.01). Conclusion: The combination of ipratropium bromide and budesonide is effective in treating acute exacerbation of childhood asthma. The administration method is simple, convenient, inexpensive, and has good compliance in children. It is worthy of clinical application.