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This study established a rat model of cerebral hemorrhage by injecting autologous anticoagulated blood. Rat models were intragastrical y administered 5, 10, 20 g/kg Poxue Huayu and Tianjing Bu-sui Decoction, supplemented with Hirudo, raw rhubarb, raw Pol en Typhae, gadfly, Fructrs Tricho-santhis, Radix Notoginseng, Rhizoma Acori Talarinowi , and glue of tortoise plastron, once a day, for 14 consecutive days. Results demonstrated that brain water content significantly reduced in rats with cerebral hemorrhage, and intracerebral hematoma volume markedly reduced after treatment. Immunohistochemical staining revealed that brain-derived neurotrophic factor, tyrosine kinase B and vascular endothelial growth factor expression noticeably increased around the surrounding hematoma. Reverse transcription-PCR revealed that brain-derived neurotrophic factor and tyrosine kinase B mRNA expression significantly increased around the surrounding hematoma. Neurologic impairment obviously reduced. These results indicated that Poxue Huayu and Tianjing Busui De-coction exert therapeutic effects on cerebral hemorrhage by upregulating the expression of brain-derived neurotrophic factor.