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目的探讨(1,3)-β-D-葡聚糖及血清降钙素原(PCT)等炎症指标在真菌性血流感染中的作用。方法回顾性分析2014年9月-2016年3月温州医科大学附属第一医院血培养阳性且为单一真菌的血流感染患者的临床资料,分析(1,3)-β-D-葡聚糖、PCT等炎症指标在真菌性血流感染中的作用。结果血流真菌感染组、局部真菌感染组血浆(1,3)-β-D-葡聚糖、NEU百分比、PLT、CRP水平高于对照组,差异有统计学意义(P<0.01);G试验、PLT检测结果真菌血流感染组与局部真菌感染组比较,差异有统计学意义(P<0.01);WBC、NEU百分比、CRP、PCT检测结果比较,差异无统计学意义。(1,3)-β-D-葡聚糖、NEU百分比、PLT、CRP检测结果显示,非白色念珠菌组与对照组比较,差异有统计学意义(P<0.05);而WBC、PCT检测结果比较,差异无统计学意义(P>0.05)。结论血浆(1,3)-β-D-葡聚糖、CRP、NEU百分比、PLT可作为真菌性血流感染的诊断参考依据;血浆(1,3)-β-D-葡聚糖、PLT与真菌性血流感染严重程度有关。
Objective To investigate the role of inflammatory markers such as (1,3) -β-D-glucan and serum procalcitonin (PCT) in fungal bloodstream infections. Methods The clinical data of patients with bloodstream infection who were positive for blood culture and single fungus in the First Affiliated Hospital of Wenzhou Medical University from September 2014 to March 2016 were retrospectively analyzed. The levels of (1,3) -β-D-glucan , PCT and other inflammatory markers in fungal bloodstream infection. Results The levels of plasma (1,3) -β-D-glucan, NEU, PLT and CRP in bloodstream fungal infection group and local fungal infection group were significantly higher than those in control group (P <0.01) Test, PLT test results Fungal bloodstream infection group and local fungal infection group, the difference was statistically significant (P <0.01); WBC, NEU percentage, CRP, PCT test results, the difference was not statistically significant. (1, 3) -β-D-glucan, NEU percentage, PLT and CRP showed that there was significant difference between non-Candida albicans group and control group (P <0.05) Results, the difference was not statistically significant (P> 0.05). Conclusions The plasma (1,3) -β-D-glucan, the percentage of CRP and NEU, and the PLT can be used as reference for the diagnosis of fungal bloodstream infection. Plasma (1,3) Fungal bloodstream infection with the severity.