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本报道多沙唑嗪和哌唑嗪治疗轻、中度高血压病的随机、双盲、多中心研究。 252例患者随机分成多沙唑嗪组和哌唑嗪组,每组126例。经4周安慰剂后,进入12周治疗期。多沙唑嗪每日1次,日维持量为0.5mg的34例、1mg 23例、2mg 33例、4mg 36例,平均1.98 mg;哌唑嗪每日3次,日维持量为1.5 mg的31例、3mg 30例、4.5mg30例、6mg 35例,平均3.82mg。结果两组血压于治疗后第2周已显著下降,并继续下降,至第8周时稳定。治疗后
This report of doxazosin and prazosin treatment of mild to moderate hypertension in a randomized, double-blind, multicenter study. 252 patients were randomly divided into doxazosin group and prazosin group, 126 cases in each group. After 4 weeks of placebo, into the 12-week treatment period. Doxazosin once daily, the daily maintenance dose of 0.5mg 34 cases, 1mg 23 cases, 2mg 33 cases, 4mg 36 cases, an average of 1.98 mg; prazosin three times daily, the daily maintenance dose of 1.5 mg 31 cases, 3mg 30 cases, 4.5mg30 cases, 6mg 35 cases, an average of 3.82mg. Results The blood pressure of the two groups dropped significantly at the second week after treatment and continued to decline until the 8th week. After treatment