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目的：研究哮喘时肺表面活性物质（ｐｕｌｍｏｎａｒｙｓｕｒｆａｃｔａｎｔ，ＰＳ）系统超微结构的变化。方法：运用电子显微镜组织化学方法，对哮喘豚鼠ＰＳ系统进行观察。结果：致敏豚鼠诱发哮喘后即可见ＰＳ层失去连续性，呈现断裂或堆积；肺泡Ⅱ型细胞内板层小体、线粒体空泡化，少数发生坏死并崩解、脱落进入肺泡腔。结论：ＰＳ系统损伤在哮喘发生发展中可能有重要的意义。
Objective: To study the ultrastructural changes of pulmonarysurfactant (PS) system in asthma. Methods: Electron microscope histochemical methods were used to observe the PS system of asthmatic guinea pigs. Results: After the sensitized guinea pigs developed asthma, the PS layer lost its continuity and showed rupture or accumulation. The lamellar bodies and mitochondria of alveolar type Ⅱ cells were vacuolized, and a few necrotic and disintegrated into the alveolar space. Conclusion: PS system injury may play an important role in the development of asthma.