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作者调研了75例成人急性髓性白血病(AML)患者白血病祖细胞(CFU—AML)自我更新能力(PE_2)、对阿糖胞苷和柔红霉素的体外敏感性,并测定P—糖蛋白(P—gp)的表达,以探测所得结果与诱导疗效的关系。 材料和方法 75例新诊断的成人AML,诊断和分类按照FAB标准。包括M_1型14例、M_2型19例、M_3型10例、M_4型18例、M_5型12例,M_6型2例。中位数
The authors investigated the in vitro chemosensitivity to cytarabine and daunorubicin in vitro of the ability of self-renewal of leukemic progenitor cells (CFU-AML) from 75 adults with acute myelogenous leukemia (AML), and the determination of P-glycoprotein (P-gp) expression in order to explore the relationship between the results obtained and the induction of efficacy. Materials and Methods 75 cases of newly diagnosed adult AML were diagnosed and classified according to FAB criteria. Including 14 cases of M_1 type, 19 cases of M_2 type, 10 cases of M_3 type, 18 cases of M_4 type, 12 cases of M_5 type and 2 cases of M_6 type. median