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目的:鉴别、定量测定牛黄解毒片中冰片,考察非法添加樟脑的情况,为牛黄解毒片质量标准的进一步完善提供依据。方法:GC法;色谱柱:HP-INNOWAX 19091N-213(30m×0.320mm×0.50μm);检测器:FID;柱温:140℃。结果:冰片线性范围:20～500μg·ml~(-1),r=0.9997(n=5),回收率为99.5%,RSD为1.6%(n=6);樟脑线性范围:5～500μg·ml~(-1),r=0.999 6(n=5),回收率为100.2%,RSD为1.5%(n=6)。结论:不同厂家生产的牛黄解毒片中冰片的含量差异较大,存在非法添加樟脑的情况。该方法简便,快速,准确,可有效控制牛黄解毒片中冰片的质量。
OBJECTIVE: To identify and quantitatively determine borneol in Niuhuangjiedu tablets and investigate the situation of illegally adding camphor, and provide basis for further improving the quality standard of Niuhuangjiedu tablets. Method: GC method; Column: HP-INNOWAX 19091N-213 (30m × 0.320mm × 0.50μm); Detector: FID; Results: The linear range of borneol was 20 ~ 500μg · ml ~ (-1), r = 0.9997 (n = 5), the recovery was 99.5% and RSD was 1.6% (n = 6) ml -1, r = 0.999 6 (n = 5). The recovery was 100.2% and the RSD was 1.5% (n = 6). Conclusion: The contents of borneol in Niuhuangjiedu tablets produced by different manufacturers are quite different, and the camphor is illegally added. The method is simple, rapid and accurate, which can effectively control the quality of borneol tablets in Niuhuang Jiedu tablets.