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目的探讨他汀类药物对出血性脑卒中患者预后的影响。方法对365例出血性脑卒中患者的临床资料进行回顾性分析,分析他汀类药物的使用及停用是否与出血性脑卒中患者预后的改善及预后的恶化的关系。结果住院期间接受他汀类药物患者的30d病死率为10.38%低于住院期间未接受他汀类药物患者的25.10%(P<0.05),出院或住院康复率为56.60%高于住院期间未接受他汀类药物患者的39.77%(P<0.05);住院期间未停用他汀类药物患者的30d病死率为11.48%显著低于住院期间停用他汀类药物的42.00%(P<0.05),出院或住院康复率为57.38%显著高于住院期间停用他汀类药物患者的44.00%(P<0.05)。结论他汀类药物能够改善ICH患者的预后状况,并且他汀类药物的停用与ICH患者预后的恶化相关。考虑到他汀类药物停用与预后恶化间的关系,在ICH急性期,应该慎重权衡他汀类药物停用的风险与收益。
Objective To investigate the effect of statins on the prognosis of patients with hemorrhagic stroke. Methods The clinical data of 365 patients with hemorrhagic stroke were analyzed retrospectively to analyze whether the use and discontinuation of statins were related to the prognosis and the prognosis of hemorrhagic stroke patients. Results The 30-day mortality of patients receiving statins during hospitalization was lower than that of patients receiving statins by 10.38% (P <0.05). The rate of discharged or hospitalized patients was 56.60% higher than that of patients not receiving statins during hospitalization (P <0.05). The 30-day mortality rate of 11.48% of the patients who did not use statins during hospitalization was significantly lower than that of statins (42.00%) during hospitalization (P <0.05). The discharge or in-hospital rehabilitation The rate was 57.38%, which was significantly higher than 44.00% (P <0.05) of those patients who stopped using statins during hospitalization. Conclusions Statins can improve the prognosis of patients with ICH, and the discontinuation of statins is associated with worsening prognosis in patients with ICH. Given the relationship between statin withdrawal and worsening prognosis, the risks and benefits of statin withdrawal should be carefully weighed during the acute phase of ICH.