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目的 :研究新化合物葛根 4’ 氧代乙酸 7 羟乙氧基 黄豆苷元 (DZ18)的主要药效学。方法 :采用小鼠急性毒性实验 ,脑缺血实验 ,常压耐缺氧实验 ,KCN中毒实验 ,跳台实验 ,考察DZ18的药效学结果。结果 :DZ18可显著延长小鼠存活时间 ,并对东莨菪碱所致小鼠记忆获得障碍有显著改善作用。结论 :DZ18作为一种全新化合物 ,对心脑血管作用明显。
PURPOSE: To study the main pharmacodynamics of the new compound Pueraria lobata 4 hydroxyacetate 7 hydroxy ethoxy daidzein (DZ18). METHODS: The mouse acute toxicity test, cerebral ischemia test, atmospheric hypoxia tolerance test, KCN poisoning test, and step-down test were used to examine the pharmacodynamic results of DZ18. RESULTS: DZ18 significantly prolonged the survival time of mice and significantly improved the memory impairment of mice induced by scopolamine. Conclusion :DZ18 is a brand-new compound with obvious effects on cardiovascular and cerebrovascular.