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目的:探讨survivin、微血管密度和微淋巴管密度在食管腺癌淋巴结转移中的作用。方法:采用免疫组织化学方法检测41例食管腺癌survivin的表达情况,并对微血管密度和微淋巴管密度计数。结果:淋巴结转移患者survivin阳性率为84.62%,淋巴结未转移患者survivin阳性率为53.3%。survivin阳性患者微血管密度明显高于阴性患者(P<0.01)。结论:食管腺癌中survivin与淋巴结转移有关,survivin的表达与微血管密度有关。
Objective: To investigate the role of survivin, microvessel density and lymphatic vessel density in lymph node metastasis of esophageal adenocarcinoma. Methods: Immunohistochemistry was used to detect the expression of survivin in 41 cases of esophageal adenocarcinoma, and the counts of microvessel density and lymphatic vessel density were calculated. Results: The positive rate of survivin in patients with lymph node metastasis was 84.62%. The positive rate of survivin in patients with lymph node metastasis was 53.3%. The microvessel density of survivin positive patients was significantly higher than that of negative patients (P <0.01). Conclusions: The expression of survivin in esophageal adenocarcinoma is related to the lymph node metastasis.