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目的提出一种基于生存分析统计技术的结核病患者治疗依从性的评价方法。方法将退出疗程作为所关心的结局事件,将从登记治疗开始到退出疗程的时间作为坚持治疗时间,利用生存分析统计技术估计坚持治疗率和中位坚持治疗时间以评价结核病患者的治疗依从性。结果将本文所提方法应用于重庆市某区结核病患者治疗管理数据的结果显示:所提方法可以对包括未完成疗程患者在内的结核病患者的治疗依从性进行评价,并同时调整治疗失败、迁出、死亡对评价结果的影响。初治患者5月末的坚持治疗率为0.7406,复治患者7月末的坚持治疗率接近0。初、复治患者的中位坚持治疗时间分别为1.97个月和1.03个月。结论本文所提方法是一种更合理的结核病患者治疗依从性的评价方法,对现行的结核病管理工作具有实际意义。
OBJECTIVE: To propose a method to evaluate the treatment compliance of patients with tuberculosis based on survival analysis and statistical techniques. Methods The withdrawal course was taken as the outcome event of interest. The time from the start of registration to the withdrawal of treatment was used as the treatment duration. Survival analysis was used to estimate the adherence rate and the median treatment duration to evaluate the treatment compliance of TB patients. Results The results of applying this method to treatment management data of tuberculosis patients in a district of Chongqing show that the proposed method can evaluate the treatment compliance of patients with tuberculosis including patients with incomplete treatment and at the same time adjust the treatment failure, Out, death on the evaluation results. The initial treatment of patients adhere to the end of May treatment rate was 0.7406, retreatment patients adhere to the end of July treatment rate close to 0. The median duration of treatment for primary and re-treatment patients was 1.97 months and 1.03 months respectively. Conclusion The method proposed in this paper is a more reasonable assessment of treatment adherence of patients with tuberculosis, which is of practical significance to the current TB management.