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多数获得性再生障碍性贫血(简称再障)是T细胞介导的自身免疫性疾病。儿童再障强化免疫抑制治疗(intensiveimmunosuppressivetherapy,IIST)有效率达71.8%,但至今未有明确的疗效预测指标。采用流式细胞术观察20例特发性再障儿童外周血辅助性T细胞(helper-Tcell,Th)亚型(Th1、Th2)和细胞毒T细胞(cytotoxic-Tcell,Tc)亚群(Tc1、Tc2)水平,试图探讨Th1/Th2、Tc1/Tc2改变与病情、免疫抑制治疗(immunosuppressivetherapy,IST)疗效的关系。
Most acquired aplastic anemia (referred to as aplastic anemia) is a T cell-mediated autoimmune disease. Intensive immunosuppressive treatment of childhood aplasia (intensiveimmunosuppressivetherapy, IIST) effective rate of 71.8%, but so far no clear prediction of the efficacy of the index. Flow cytometry was used to detect the subsets of helper-Tcell (Th) and cytotoxic T cells (Tc) in 20 children with idiopathic aplastic anemia (Tc1 , Tc2) levels in order to explore the Th1 / Th2, Tc1 / Tc2 changes and disease, immunosuppressive therapy (immunosuppressive therapy, IST) efficacy.