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目的对存在营养不良的肝功能衰竭患者制定相应营养干预措施,以了解营养干预对肝功能衰竭患者的疗效。方法选取2014年1-8月在解放军第81医院全军肝病中心住院的44例营养不良肝功能衰竭患者为研究对象,按入院先后将其分为观察组和对照组两组,对照组给予内科综合治疗,观察组在常规内科治疗基础上针对营养评估的结果进行营养干预,观测并比较干预前与干预后两组患者的营养生化指标、人体测量营养相关指标、主观全面评价法(subjective global assessment,SGA)评分及并发症发生情况。结果干预前,两组患者的营养生化指标、人体测量指标及SGA评分的差异均无统计学意义(均P>0.05);干预后,观察组患者的营养生化指标[除白蛋白(albumin,ALB)外]、身体质量指数(body mass index,BMI)及SGA评分均优于对照组(均P<0.05);干预后,观察组患者的营养生化指标[除胆固醇(cholesterol,TC)外]、BMI、上臂围(mid-arme circumference,MAC)及SGA评分均优于干预前(均P<0.05);对照组患者的SGA评分优于干预前(P<0.05),其余指标与干预前比较,差异均无统计学意义(均P>0.05)。干预后,观察组患者并发症的发生率低于对照组,差异有统计学意义(P<0.05)。结论营养干预有利于改善营养不良肝功能衰竭患者的营养状态,减少并发症的发生。
Objective To develop nutritional interventions for patients with liver dysfunction who have malnutrition to understand the effects of nutritional intervention on patients with liver failure. Methods From January to August 2014, 44 patients with malnutrition liver failure hospitalized in PLA General Hospital of Liver Diseases, People’s Liberation Army General Hospital were enrolled and divided into observation group and control group according to hospital admission. The control group was given internal medicine In the comprehensive treatment, the observation group conducted nutritional intervention on the basis of routine medical treatment according to the results of nutritional assessment, and observed and compared the nutritional biochemical indexes, the nutrition related indexes of human body measurement, the subjective global assessment , SGA) score and complications. Results Before intervention, the nutritional biochemical indexes, anthropometric indexes and SGA scores were not significantly different between the two groups (all P> 0.05). After intervention, the nutritional biochemical indexes [albumin (ALB) ), Body mass index (BMI) and SGA score were better than those in the control group (all P <0.05). After intervention, the patients’ nutritional and biochemical indexes [except cholesterol (TC) The scores of BMI, mid-arme circumference (MAC) and SGA were better than those before intervention (all P <0.05). The scores of SGA in control group were better than those before intervention (P <0.05) There was no significant difference (all P> 0.05). After the intervention, the incidence of complication in the observation group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Nutritional intervention is helpful to improve the nutritional status of patients with malnutrition liver failure and reduce the incidence of complications.