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目的:探讨经尿道膀胱肿瘤电切术联合膀胱灌注在治疗膀胱肿瘤中的临床效果。方法:选择我院2012年2月~2016年2月期间经尿道膀胱肿瘤电切术治疗膀胱肿瘤患者65例,术后定期给予丝裂霉素C、噻替哌、吡柔比星等药物膀胱腔内灌注化疗,并定期随访,观察患者术后复发及不良反应等情况。结果:本组65例患者经尿道膀胱肿瘤电切术后膀胱肿瘤复发率36.7%、不良反应发生率33.8%,且复发率随着膀胱肿瘤病理分级的增高而逐渐增高,相互之间差异具有统计学意义;电切术后联合膀胱灌注治疗,复发率16.7%、不良反应发生率15.4%,与单纯的电切术治疗相比,复发率和不良反应发生率差异均具有统计学意义;三种不同灌注药物治疗患者的复发率及不良反应发生率差异均无统计学意义。结论:采用经尿道膀胱肿瘤电切术联合膀胱灌注治疗膀胱肿瘤,二者相得益彰,可以有效降低术后膀胱肿瘤的复发率,减少不良反应,提高治疗效果,值得临床进一步推广与应用。
Objective: To investigate the clinical effect of transurethral resection of bladder tumor combined with intravesical instillation in the treatment of bladder cancer. Methods: Totally 65 patients with bladder tumor were treated by transurethral resection of bladder tumor from February 2012 to February 2016 in our hospital. After operation, the bladder of mitomycin C, thiotepa and pirarubicin were given regularly Intraluminal chemotherapy, and regular follow-up, observation of patients with postoperative recurrence and adverse reactions. Results: The recurrence rate of bladder tumor was 36.7% and the incidence of adverse reactions was 33.8% in 65 cases of transurethral resection of bladder tumor, and the recurrence rate was gradually increased with the increase of pathological grade of bladder tumor, the difference was statistically significant Significance of resection; Combined resection of bladder irrigation after resection, the recurrence rate was 16.7%, the incidence of adverse reactions was 15.4%, compared with the simple resection, the recurrence rate and the incidence of adverse reactions were statistically significant; three There was no significant difference in the recurrence rate and the incidence of adverse reactions between different perfusion drug treatment patients. Conclusion: Transurethral resection of bladder tumor combined with intravesical instillation of bladder tumor can complement each other effectively, which can effectively reduce the recurrence rate of postoperative bladder cancer, reduce adverse reactions and improve the therapeutic effect, which deserves further clinical application.