【摘 要】
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Members in the family Herpesviridae share a common architecture: the outer envelope, the inner nucleocapsid and the in-between tegument.There are three types of
【机 构】
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Cryo-Electron Microscopy Research Center, the CAS Key Laboratory of Receptor Research, Shanghai Inst
论文部分内容阅读
Members in the family Herpesviridae share a common architecture: the outer envelope, the inner nucleocapsid and the in-between tegument.There are three types of capsids,A-, B-and C-capsids, which are matured from the procapsid.The procapsid is assembled in the host cell nucleus where the viral dsDNA genome is packaged.The viral genome is driven into the procapsid by the terminase through the portal,which locates at a unique vertex of the icosahedral capsid (Heming et al., 2017).The A-capsid is empty and is believed to be resulted from unsuccessfully packaging of viral genome.B-capsid contains the scaffold similar to that of the procapsid and is likely resulted from failed initiation of viral DNA packaging.C-capsid contains the full-length viral genome and is able to further mature into the infectious virion.
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