目的:研究食用槟榔及药用槟榔中主要化学成分的含量差异。方法:采用高效液相色谱法(HPLC)和磷钼钨酸/干酪素紫外-可见分光光度法(UV)分别测定药用槟榔饮片、食用槟榔中槟榔碱和鞣质的含量,并采用方差分析和主成分分析法对主要成分的含量进行多元统计分析。结果:针对槟榔碱和鞣质的含量,药用槟榔3种制品均与食用槟榔存在显著差异(P<0.05),且食用槟榔中槟榔碱和鞣质含量均明显低于药用槟榔。食用槟榔及药用槟榔可以进行区分,但无法对药用槟榔的不同炮制组进行区分。结论:被认定为一级致癌物的食用槟榔中槟榔碱和鞣质成分的含量明显低于药用槟榔,因此,针对毒效成分含量更高的药用槟榔饮片,其是否会对人体造成潜在性损害的问题应得到重视。 Objective: To study the difference of the main chemical components in betel nut and medicinal betel nut. Methods: The contents of arecoline and tannin in betel nut were determined by HPLC and phosphomolybdotungstic acid / casein UV-Vis spectrophotometry respectively. And principal component analysis of the main components of the content of multivariate statistical analysis. Results: The contents of arecoline and tannin in betel nut were significantly different from those in betel nut (P <0.05), and the contents of arecoline and tannin in betel nut were all significantly lower than those of betel nut. Canned betel nut and medicinal areca can be distinguished, but can not distinguish between the different processing group of medicinal areca. Conclusion: The content of arecoline and tannin in betel nut which is considered as carcinogen of first grade is obviously lower than that of betel nut. Therefore, whether betel nut tablets with higher content of toxic ingredients can cause potential to human body The issue of sexual harm deserves attention.