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对糖尿病和肥胖病病因学研究的不断发展使许多单基因糖尿病和肥胖病被发现。对中国人已开展的青少年发病型成人糖尿病、线粒体糖尿病、黑皮素4受体(MC4R)及部分伴糖尿病的遗传综合征的研究提示,单基因肥胖病及糖尿病存在种族、遗传和临床特点的异质性。对这些特殊类型糖尿病和肥胖病的深入认识将有助于对疾病的病因细致分类和个体化治疗的指导。
The ongoing development of etiologies for diabetes and obesity has led to the discovery of many monogenic diabetes and obesity. Studies on the genetic syndromes of adolescent-onset adult-onset diabetes, mitochondrial diabetes mellitus, melanocortin 4 receptor (MC4R), and some with diabetes in Chinese have suggested that there are racial, genetic and clinical features of single-gene obesity and diabetes Heterogeneity. In-depth knowledge of these particular types of diabetes and obesity will help guide the meticulous classification and individualized treatment of the etiology of the disease.