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目的观察口服降糖药联合甘精胰岛素治疗2型糖尿病的临床效果。方法将90例2型糖尿病患者随机分为观察组和对照组各45例,对照组口服格列吡嗪控释片治疗;观察组在此基础上予以甘精胰岛素皮下注射治疗,观察2组空腹血糖(FPG)、餐后2h血糖(2h PG)、空腹C肽(FCP)、餐后2h C肽(2h CP)、糖化血红蛋白(Hb A1c)的变化及低血糖事件。结果观察组患者FPG、2h PG、Hb A1c、FCP、2h CP改善程度明显优于对照组,且观察组低血糖事件发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论口服降糖药联合甘精胰岛素治疗2型糖尿病效果明显,可减少低血糖事件概率,提高安全性,值得临床应用推广。
Objective To observe the clinical effect of oral hypoglycemic agents combined with insulin glargine in the treatment of type 2 diabetes mellitus. Methods Ninety patients with type 2 diabetes mellitus were randomly divided into observation group (45 cases) and control group (45 cases). The control group was treated with glipizide controlled-release tablets. The observation group was treated with insulin glargine subcutaneously. The fasting Blood glucose (FPG), postprandial 2h blood glucose (2h PG), fasting C-peptide (FCP), postprandial 2h C peptide, Hb A1c and hypoglycemic events. Results The improvement rate of FPG, 2h PG, Hb A1c, FCP and 2h CP in the observation group was significantly better than that in the control group. The incidence of hypoglycaemia in the observation group was significantly lower than that of the control group (P <0.05). Conclusion Oral hypoglycemic agents combined with insulin glargine treatment of type 2 diabetes obvious effect, can reduce the probability of hypoglycemic events, improve safety, it is worth promoting the clinical application.