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c-Jun N-terminal protein kinases (JNK),also known as stress-activated proteinkinases,were originally identified by their ability to phosphorylate the N-terminalof the transcription factor c-Jun and by their activation in response to a variety ofstresses.JNK are multifunctional kinases involved in many physiologicalprocesses.The JNK pathway has been shown to play a major role in apoptosis inmany cell death paradigms and its association with a variety of pathological pro-cesses is gradually been recognized.This review will concentrate on describingthe involvement of the JNK pathway in the context of different diseases and thepotential to adopt the JNK pathway components as therapeutic targets.
c-Jun N-terminal protein kinases (JNK), also known as stress-activated proteinkinases, were originally identified by their ability to phosphorylate the N-terminal of the transcription factor c-Jun and by their activation in response to a variety of stresses. JNK are multifunctional kinases involved in many physiological processes. The JNK pathway has been shown to play a major role in apoptosis inmany cell death paradigms and its association with a variety of pathological pro-cesses is gradually been recognized. This review will concentrate on describing the involvement of the JNK pathway in the context of different diseases and the potential to adopt the JNK pathway components as therapeutic targets.