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目的探讨口服α1-受体阻滞剂盐酸坦索罗辛缓释胶囊加直肠给药消炎痛栓对慢性非细菌性前列腺炎(CNP)的临床治疗效果。方法自2008年2月至2010年2月选择门诊CNP患者进行随机对照研究,实验组74例,口服盐酸坦索罗辛缓释胶囊联合直肠给药消炎痛栓;对照组72例,只口服盐酸坦索罗辛缓释胶囊,比较两组治疗效果。结果实验组治疗总有效率,症状减轻程度明显高于对照组,复发率明显低于对照组(P<0.05)。结论盐酸坦索罗辛缓释胶囊可缓解膀胱颈口的紧张度,降低后尿道阻力,减轻CNP引起的排尿困难症状;消炎痛栓直肠给药其有效成分可穿透组织到达前列腺炎症区域,缓解慢性炎症反应,减轻CNP所引起的疼痛和下尿路症状(LUTS)。
Objective To investigate the clinical effect of oral administration of tamsulosin hydrochloride sustained-release capsules and rectally administered indomethacin suppositories on chronic nonbacterial prostatitis (CNP). Methods From July 2008 to February 2010, randomized controlled trials were conducted in outpatients with CNP. Totally 74 patients in the experimental group were given oral tamsulosin hydrochloride sustained-release capsules and indomethacin suppositories. In the control group, 72 patients were given oral hydrochloric acid Tamsulosin sustained release capsules, the two groups were compared. Results The total effective rate and symptom relief in the experimental group were significantly higher than those in the control group, and the recurrence rate was significantly lower than that in the control group (P <0.05). Conclusion Tamsulosin hydrochloride sustained-release capsules can relieve the tension of the bladder neck and mouth, reduce the urethral resistance and relieve the symptoms of dysuria caused by CNP. Indomethacin suppository can effectively penetrate the tissue to reach the prostatitis area and relieve the symptoms of dysuria. Chronic inflammatory reactions reduce CNP-induced pain and lower urinary tract symptoms (LUTS).