目的 探讨盐酸氨溴索联合曲安奈德对分泌性中耳炎(SOM)患者T淋巴细胞亚群的影响.方法 选择110例单耳SOM患者作为观察对象,采用随机数表法分为观察组55例和对照组55例.对照组予以地塞米松治疗,观察组采用盐酸氨溴索联合曲安奈德治疗.比较两组治疗效果、中耳积液炎症因子[白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)、降钙素原(PCT)]与免疫指标(CD4+、CD8+、CD4+/CD8+).结果 对照组治疗总有效率低于观察组,差异有统计学意义(P＜0.05);治疗后观察组IL-8、TNF-α、PCT等指标水平均显著低于对照组,差异有统计学意义(P＜0.05);与对照组相比,观察组CD4+及CD4+/CD8+指标水平均较高,而CD8+水平较低,差异有统计学意义(P＜0.05).结论 SOM采用盐酸氨溴索联合曲安奈德治疗可明显改善患者的免疫功能,提高临床治疗效果,值得临床进一步推广应用.“,”Objective To explore the influence of Ambroxol Hydrochloride joint Triamcinolone acetonide T lymphocyte subsets in patients with secretory otitis media (SOM).Methods select our hospital 110 cases of single ear SOM patients as research object,using the stochastic indicator method 55 patients were divided into observation group and control group 55 cases.Control group dexamethasone therapy,observation group with Ambroxol Hydrochloride joint Triamcinolone acetonide treatment.Compared treatment effect of two groups,inflammation of the middle ear effusion factor [interleukin 8 (IL-8),tumor necrosis factor alpha (TNF alpha),calcitonin (PCT)] and immune indexes (CD4+,CD8 +,CD4 +/CD8 +).Results In the control group total effective rate is lower than the observation group,the difference was statistically significant (P ＜ 0.05);Observation group after treatment IL-8,TNF alpha,indices such as PCT levels were significantly lower than those the control group,the difference was statistically significant (P ＜ 0.05);Compared with control group,the observation group of CD4 + and CD4 +/CD8 + index levels are higher,and the low level of CD8 +,the difference was statistically significant (P ＜ 0.05).Conclusion SOM using Ambroxol Hydrochloride joint Triamcinolone acetonide treatment can obviously improve the patient's immune function,improve the effect of clinical treatment,is worth further clinical application.