论文部分内容阅读
目的:研究髓过氧化物酶(MPO)与慢性心力衰竭(CHF)及CHF严重程度的关系。方法:选取连续入院的74名NYHAⅡ~Ⅳ级的CHF患者及55名作为对照的非CHF患者,采用ELISA法测量其血清MPO浓度。采用多元线性回归分析血清MPO水平与CHF及其严重程度的关系。结果:在调整了混杂因素后,CHF患者血清MPO水平显著高于对照组[(16±5)μg/Lvs.(9±4)μg/L,P<0.01],并随着NYHA分级的增加而升高(r=0.34,P<0.01)。结论:血清MPO浓度在CHF患者中升高,并且与CHF严重程度相关。
Objective: To investigate the relationship between myeloperoxidase (MPO) and chronic heart failure (CHF) and the severity of CHF. Methods: Seventy-four CHF patients with NYHA class Ⅱ ~ Ⅳ and 55 non-CHF patients as control were enrolled in this study. Serum MPO concentration was measured by ELISA. The relationship between serum MPO level and CHF and its severity was analyzed by multivariate linear regression. RESULTS: After adjusting for confounding factors, serum MPO levels in patients with CHF were significantly higher than those in controls [(16 ± 5) μg / L vs (9 ± 4) μg / L, P <0.01] But increased (r = 0.34, P <0.01). CONCLUSIONS: Serum MPO levels are elevated in CHF patients and correlated with the severity of CHF.