论文部分内容阅读
抗精神病药物主要分为第一代抗精神病药(FGA)和第二代抗精神病药(SGA)。自1952年氯丙嗪问世至今,抗精神病药物已经历了半个世纪的发展。由于氯丙嗪的抗精神病作用与阻滞多巴胺D2受体有关,随之发展了一系列D2受体阻断剂的传统抗精神病药物,包括氟哌啶醇、奋乃静、舒必利、三氟拉嗪、氯普噻吨、五氟利多和硫利达嗪等,即FGA,又称典型抗精神病药。上世纪六十年代末出现了氯氮平,疗效好且锥体外系反应(EPS)少,因与多种受体有亲和力故
Antipsychotics are divided into first-generation antipsychotics (FGA) and second-generation antipsychotics (SGA). Since the advent of chlorpromazine in 1952, antipsychotic drugs have experienced half a century of development. Since the antipsychotic effect of chlorpromazine is linked to the blockade of the dopamine D2 receptor, a series of traditional antipsychotics such as haloperidol, perphenazine, sulpiride, trifluralin Triazine, chlorprothixene, pentafluoridol and thioridazine, etc., that is, FGA, also known as typical antipsychotics. Clozapine appeared at the end of the sixties of the last century, with good curative effect and less extrapyramidal reaction (EPS) due to its affinity with various receptors