1986年5月在澳大利亚召开了国际铁与肝脏研究专题讨论会,总结和研讨了铁和肝脏的研究现状,现将主要内容整理如下:铁代谢红细胞和肝细胞内铁主要来自转铁蛋白,转铁蛋白通过受体介导的细胞摄粒作用进入细胞,然后将铁释放到细胞内小囊,经酸化还原为亚铁状态,转铁蛋白再循环到细胞表面.在肝细胞内,比较多的铁组成铁蛋白,少量合成血红素.肝细胞内铁的其他来源包括:血清铁蛋白、结合珠蛋白-血红蛋白和血结合素-血红素,所有这些都是通过受体介导的细胞摄粒作用而吸收的.Cook强调几乎四分之一的世界人口患有主要由铁的缺乏而引起的贫血.围产期母体缺铁有很大危害,可以影响胎儿脑和身体的发育.正常人群和缺铁人群之间的实验室检查值有明显的重迭.Cook介绍了一种对人体铁贮备作定量的技术,方法是同时测定血红蛋白、转铁蛋白饱和度、红细胞原卟啉以及血清铁蛋白.美国 In May 1986, the International Symposium on Iron and Liver Research was held in Australia to summarize and discuss the research status of iron and liver. The main contents are as follows: Iron Metabolism Red blood cells and iron in liver cells are mainly from transferrin, Ferritin enters the cell via receptor-mediated cellular uptake, then releases iron to the intracellular vesicle, which is reduced to the ferrous state by acidification, and transferrin is recycled to the cell surface. In hepatocytes, more Iron forms ferritin, a small amount of synthetic heme.Other sources of intrahepatic iron include: serum ferritin, haptoglobin-hemoglobin and hemopexin-heme, all of which are mediated through receptor-mediated cellular uptake The absorbed .Cook emphasizes that almost a quarter of the world’s population suffer from anemia mainly caused by the lack of iron. Perinatal maternal iron deficiency has a great harm, can affect fetal brain and body development .Normal people and lack of There is a clear overlap between laboratory tests of iron populations and Cook introduced a technique for quantifying human iron stores by simultaneously measuring hemoglobin, transferrin saturation, erythrocyte protoporphyrin As well as serum ferritin