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目的 研究窒息新生儿应激状态下内分泌改变以指导临床抢救及判断预后。方法 检测３８例新生儿血中Ｔ３、Ｔ４、胰岛素、皮质醇水平，实验组为２０例窒息新生儿，对照组为１８例新生儿肺炎和上呼吸道感染患儿。结果 实验组Ｔ３、Ｔ４低于对照组（Ｐ＜０．０１），而胰岛素、皮质醇水平高于对照组（Ｐ＜０．０１）。结论 Ｔ３和皮质醇可作为判断窒息新生儿预后的指标，持续监测窒息新生儿的内分泌变化可以提供判断预后的证据，还可及时采取相应正确的治疗措施以减少应激反应对机体的损害。
Objective To study endocrine changes under stress in neonatal asphyxia to guide clinical rescue and prognosis. Methods The blood levels of T3, T4, insulin and cortisol were measured in 38 neonates. The experimental group was 20 neonates with asphyxia and the control group with 18 neonates with pneumonia and upper respiratory tract infection. Results The levels of T3 and T4 in the experimental group were lower than those in the control group (P <0.01), while the levels of insulin and cortisol in the experimental group were higher than those in the control group (P <0.01). Conclusion T3 and Cortisol can be used as indicators to predict the prognosis of asphyxiated neonates. Continuous monitoring of endocrine changes in neonates with asphyxia can provide evidence to judge the prognosis, and can take timely and appropriate treatment to reduce the damage to the body caused by stress reaction.