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目的:研究2型糖尿病(Type 2 Diabetes,T2DM)合并肺结核(Tuberculosis,TB)患者诱导耐药性危险因素的回归分析。方法:从2012年3月到2013年3月,于我院共计有124例患者被确诊为肺结核,将其作为研究对象。根据患者是否合并有2型糖尿病,将其分成观察组(49例)及对照组(75例)。对全部患者进行耐药性实验,分别经单因素分析及Logistic回归性分析寻找诱导耐药性的危险因素。结果:观察组在治疗过程中断、有吸烟习惯、依从性差、病程≥1年、HbAlc值≥6.5%等方面所占比例显著高于对照组,差异均有统计学意义(均P<0.05)。由多因素分析可知,治疗过程中断、有吸烟习惯、依从性差、病程≥1年、HbAlc值≥6.5%等均为糖尿病合并肺结核患者的危险因素。结论:T2DM合并TB患者诱导耐药性的危险因素较多,临床应重点关注,并采取相应措施,从而为临床治疗提供更为有利的条件。
Objective: To study the regression analysis of the risk factors of drug-induced resistance in type 2 diabetes mellitus (T2DM) patients with tuberculosis (TB). METHODS: From March 2012 to March 2013, a total of 124 patients in our hospital were diagnosed with tuberculosis as subjects. Patients were divided into observation group (49 cases) and control group (75 cases) according to whether they had type 2 diabetes mellitus or not. All patients were tested for drug resistance by single factor analysis and Logistic regression analysis to find the risk factors for induction of drug resistance. Results: The proportion of patients in the observation group who discontinued treatment, smoking habit, poor compliance, duration of disease ≥ 1 year, HbAlc value≥6.5% were significantly higher in the observation group than in the control group (all P <0.05). Multivariate analysis showed that the interruption of treatment, smoking habits, poor compliance, duration of more than 1 year, HbAlc value of 6.5% were all risk factors for patients with diabetes complicated with pulmonary tuberculosis. Conclusion: There are many risk factors for inducing drug resistance in patients with T2DM complicated with TB, and clinical focus should be given and corresponding measures should be taken to provide more favorable conditions for clinical treatment.