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目的:探讨冷刀锥切术在子宫颈上皮内瘤变后对妊娠的影响。方法:将2007年1月~2009年7月间台州医院收治因宫颈上皮内瘤变而实施冷刀锥切术,术前无不孕症,且有生育要求的妇女50例作为观察组,并随机选取同时期内产科收住的普通妊娠妇女50例作为对照组,比较两组妇女妊娠时间、经过、孕周、妊娠结局和胎儿情况。结果:观察组50例妇女术后3~6个月妊娠10例,6~12个月妊娠21例,12~30个月妊娠17例,其中早产4例,过期产2例,足月产42例;对照组50例产妇早产5例,过期产1例,足月产44例,两组数据差异无统计学意义(P>0.05)。观察组2例产妇发生胎膜早破,随后行剖宫产,胎膜早破发生率为4.2%,对照组产妇有1例发生胎膜早破,胎膜早破发生率为2.0%,两组数据差异无统计学意义(P>0.05)。观察组娩出胎儿均存活,体重(3 458±425)g,其中最低出生体重2 750 g,为1例早产儿,最高体重4 300 g,对照组胎儿体重(3 520±470)g,其中最低体重2 700 g,最高体重4 200 g,两组数据差异无统计学意义(P>0.05)。结论:冷刀锥切术治疗子宫颈上皮内瘤变疗效显著,安全可靠,对患者术后妊娠无不良影响。
Objective: To investigate the effect of cold knife conization on pregnancy after cervical intraepithelial neoplasia. Methods: From January 2007 to July 2009, Taizhou Hospital was treated with cold-knife conization because of cervical intraepithelial neoplasia. Fifty women with no infertility before pregnancy who had fertility requirements were selected as observation group and randomized Fifty cases of general pregnant women admitted to obstetrics during the same period were selected as the control group, and the gestational time, gestational age, pregnancy outcome and fetus status of the two groups were compared. Results: In the observation group, 50 cases of women received 3 to 6 months postpartum pregnancy in 10 cases, 6 to 12 months of pregnancy in 21 cases, 12 to 30 months of pregnancy in 17 cases, of which 4 cases of preterm birth, 2 cases of overdue, full-term 42 In the control group, 5 maternal premature births were found in 5 cases, 1 obsolete birth and 44 full-term births. There was no significant difference between the two groups (P> 0.05). The observation group 2 maternal premature rupture of membranes, followed by cesarean section, the incidence of premature rupture of membranes was 4.2%, 1 case of maternal premature rupture of membranes, the incidence of premature rupture of membranes was 2.0%, two There was no significant difference between groups (P> 0.05). The fetus in the observation group survived and weighed (3 458 ± 425) g, with the lowest birth weight of 2 750 g, one premature infant and the highest weight of 4 300 g. The fetus weight of the control group was (3 520 ± 470) g, of which the lowest Body weight 2 700 g, maximum body weight 4 200 g, no significant difference between the two groups of data (P> 0.05). Conclusion: Cold-knife conization for the treatment of cervical intraepithelial neoplasia has significant effect, is safe and reliable, and has no adverse effect on postoperative pregnancy.