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目的分析T2DM患者心电图T波峰末间期(Tp-Te)的变化并探讨其与室性心律失常的关系。方法选取2014年6月至2016年5月于我院内分泌科收治的T2DM患者112例(T2DM组),以同期在我院体检的65名健康体检者作为正常对照(NC)组。对比分析各组的一般资料、FPG、HbA_1c、Tp-Te、Tp-Te离散度(Tp-Ted)及T2DM组有无室性心率失常发生时患者心电图Tp-Te的变化。结果T2DM组FPG、HbA_1c、LDL-C、TC、心率均高于NC组(P<0.05);与NC组比较,T2DM组V_5导联TpTe和Tp-Ted延长(P<0.05);T2DM组室性心律失常亚组V_5导联Tp-Te和Tp-Ted均长于未发生室性心律失常亚组(P<0.05)。多因素Logistic回归分析显示,HbA_1c及FPG增高是影响Tp-Ted延长的独立危险因素,Tp-Ted是影响室性心律失常的独立危险因素。结论T2DM患者易出现Tp-Ted的延长,且Tp-Te和Tp-Ted的延长会增加室性心律失常的发生率。
Objective To analyze the changes of Tp-Te in the electrocardiogram of T2DM patients and to explore its relationship with ventricular arrhythmia. Methods One hundred and twenty T2DM patients (T2DM group) admitted to Department of Endocrinology from June 2014 to May 2016 in our hospital were selected as normal control group (NC). The changes of Tp-Te in ECG, FPG, HbA_1c, Tp-Te, Tp-Te dispersion (Tp-Ted) and T2DM patients with or without ventricular arrhythmia were compared and analyzed. Results T2DM group had higher FPG, HbA_1c, LDL-C, TC and heart rate than NC group (P <0.05). Compared with NC group, TpTe and Tp-Ted of V_5 lead in T2DM group were prolonged Tp-Te and Tp-Ted in V_5 lead of the arrhythmia subgroup were longer than those in the subgroup without ventricular arrhythmia (P <0.05). Multivariate logistic regression analysis showed that the increased HbA 1c and FPG were independent risk factors for Tp-Ted prolongation, and Tp-Ted was an independent risk factor for ventricular arrhythmia. Conclusions The prolongation of Tp-Ted is easy to occur in T2DM patients. The prolongation of Tp-Te and Tp-Ted may increase the incidence of ventricular arrhythmia.