青蒿素是中药青蒿抗疟的有效成份。青蒿素不仅具有新颖的倍半萜结构,而且又有突出的抗疟药效。我们小组进行了它的生物合成的研究,以了解自然界合成这类物质的途径,生物合成中间体的分离鉴定,中间体的同位素标记和标记了的中间体的生物转化是生物合成研究的 Artemisinin is an effective component of Chinese materia medica against malaria. Artemisinin not only has a novel sesquiterpene structure, but also has outstanding antimalarial efficacy. Our group conducted a study of its biosynthesis to understand the ways in which these substances are synthesized in nature, the isolation and identification of biosynthetic intermediates, the isotope labeling of intermediates and the biotransformation of labeled intermediates.