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目的:探讨在父系HBsAg阳性的流产胚胎中HBV-DNA感染和表达情况。方法:在仅男方感染乙型肝炎病毒HBsAg阳性组合,即女HBsAg(-)且男HBsAg(+)流产组合中,按以下组合将入选对象分为4组,组1为女HBsAb(+)且男大三阳HBeAg(+),组2为女HBsAb(+)且男小三阳HBeAg(-),组3为女HBsAb(-)且男大三阳HBeAg(+),组4为女HBsAb(-)且男小三阳HBeAg(-)。观察其胚胎绒毛HBV-DNA表达情况。结果:男方感染乙型肝炎病毒HBsAg(+)89例组合中,仅在男大三阳HBeAg(+)组合发现绒毛HBV-DNA升高。女HBsAb(-)且男HBeAg(+)组合中2例,女HBsAb(+)且男HBeAg(+)组合中1例。女方HBsAb阳性与否在男方大三阳组中子代绒毛HBV-DNA升高率差异无显著性(P>0.05)。结论:大三阳父亲更容易发生父婴垂直传播,女方HBsAb阳性与否不能完全阻断父婴垂直传播。
Objective: To investigate the HBV-DNA infection and expression in aborted fetus with HBsAg-positive abortion. METHODS: Subjects were divided into four groups, one for female HBsAb (+) and one for female HBsAg (-) and one for male HBsAg (+) abortion. Male HBsAg positive (+), female HBsAb (+) and male HBsAg (-) in group 2, female HBsAb (-) in group 3 and HBeAg (+) in male HBeAg and female HBsAb -) And male three positive HBeAg (-). Observe the expression of HBV-DNA in the embryo villus. Results: Among the 89 cases of hepatitis B virus HBsAg (+) infection, HBV-DNA of villus was found only in HBeAg (+) combination of male and female HBeAg. Female HBsAb (-) with 2 cases of male HBeAg (+) and 1 female HBsAb (+) and male HBeAg (+). The positive rate of HBsAb in the female HBsAb group was not significantly different from that of the HBsAb group (P> 0.05). Conclusion: Dasanyang father is more likely to have vertical transmission from father to infant. The positive of female HBsAb can not completely block the vertical transmission of father and baby.