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测定了１２种药物对临床分离的３０株厌氧菌和３株标准菌株的ＭＩＣ，确定甲哨唑和ｃｌａｒｉｔｈｒｏｍｙｃｉｎ对革兰氏阴性厌氧菌的抗菌活性最强，其ＭＩＣ为０．５～１μｇ／ｍｌ．其次为大环内酯９４１和国产ｃｌａｒｉｔｈｒｏｍｙｃｉｎ（４μｇ／ｍｌ）及林可霉素和红霉素（８μｇ／ｍｌ），它们对于革兰氏阳性厌氧菌（包括梭菌）及消化链球菌也有相当的活性，而环丙氟啶酸、依诺沙星、头孢克罗、环丙沙星等抗厌氧菌拟杆菌活性较低；其ＭＩＣ为１６～６４μｇ／ｍｌ。
The MIC of 12 kinds of drugs to 30 anaerobic bacteria and 3 standard strains isolated clinically was determined. It was confirmed that the antibacterial activity of metronidazole and clarithromycin on Gram-negative anaerobes was the strongest, and the MIC was 0.5 ~ 1μg / Ml. Followed by macrolide 941 and domestic clarithromycin (4 μg / ml) and lincomycin and erythromycin (8 μg / ml), which are also comparable to Gram-positive anaerobes (including Clostridia) and Peptostreptococcus While the activity of anti-anaerobic bacteria such as ciprofloxacin, enoxacin, cefaclor and ciprofloxacin was low, and the MIC was 16-64 μg / ml.