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目的:探讨他汀类药物致胰腺炎的临床特点及其关联性,为临床安全用药提供参考。方法:通过检索1970~2013年国内外科技期刊数据库,对他汀类药物致胰腺炎的相关文献进行统计和分析,提取文献中的患者年龄、性别、致ADR的药物、使用方法、联合用药、使用时间、是否再次使用、胰腺炎的严重程度等资料。结果:共检索到他汀类药物致胰腺炎的病例报告27例,其中有19例是单用一种药物引起的,其余8例都是联合用药引起;15例他汀类药物致胰腺炎发生在用药后1个月至1年内;剂量及累计摄入剂量均与胰腺炎的发生无明显相关性;经停药及对症治疗后大部分病例症状缓解,其中2例死亡。结论:他汀类药物引起胰腺炎少见,但当患者正在服用他汀类药物,并怀疑有胰腺炎症状时,提示临床医师及时关注并采取相应措施。
Objective: To investigate the clinical characteristics of statin-induced pancreatitis and its correlation, provide a reference for clinical safety medication. Methods: By searching the database of domestic and foreign sci-tech periodicals from 1970 to 2013, the related literatures of statin-induced pancreatitis were statistically analyzed and analyzed. The age, sex, ADR-induced drug, usage, combination therapy, Time, whether to use again, the severity of pancreatitis and other data. Results: A total of 27 cases of statin-induced pancreatitis were retrieved. Among them, 19 cases were caused by one drug alone and the other 8 cases were caused by combination therapy. 15 cases of statin-induced pancreatitis occurred in medication After 1 month to 1 year; dose and cumulative intake of pancreatitis have no significant correlation with the incidence; after stopping and symptomatic treatment of most cases, symptoms were relieved, of which 2 patients died. CONCLUSIONS: Statins cause rare pancreatitis, but when patients are taking statins and suspecting symptoms of pancreatitis, they prompt clinicians to pay attention and take appropriate action.