0引言恶性肿瘤传统化疗由于难以在肿瘤局部达到有效药物浓度,全身毒副作用明显等原因,疗效往往不理想。抗肿瘤药物控缓释制剂瘤体内注射进行肿瘤间质化疗具有高效、长效、剂量小、副作用小等优点,已成为当今恶性肿瘤防治研究的热点之一。在肿瘤间质化疗的控缓释制剂中,埋植剂需 0 Introduction The traditional chemotherapy of malignant tumors is difficult to achieve effective drug concentration in local tumor, systemic toxic side effects and other reasons, the effect is often not ideal. Anti-tumor drug controlled release sustained-release preparations of tumor injections of tumor interstitial chemotherapy has the advantages of high efficiency, long-term, small dose, small side effects, has become one of the hot spots in the study of prevention and treatment of malignant tumors. In the controlled release of tumor stromal chemotherapy sustained release formulations, implants need