This work was supported by National Natural Science Fund of China (81522049, 31571735, 31270007, 30900110),the“Dawn”Program of Shanghai Education Commission (16SG38), Shanghai Science and Technology Committee Project (17JC1404300, 15430502700), Zhejiang Provincial Wanren Program for Leading Talents of Science and Technology Innovation (2018R52050), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents (2018-62-3), New Century Talent Project (NECT-13-0902), Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology), Zhejiang Chinese Medical University (ZYAOX2018019).