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目的观察腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的疗效。方法将203例小儿重度黄疸性肝炎患儿随机分为研究组102例和对照组101例。研究组采用腺苷蛋氨酸联合门冬氨酸钾镁治疗,对照组采用促肝细胞生长素联合门冬氨酸钾镁治疗,比较2组患儿的治疗效果及肝功能改善情况。结果治疗后研究组的总有效率为94.1%高于对照组的83.2%,差异有统计学意义(P<0.05)。治疗前2组患儿的TBi L、ALT、PT、ALB等生化指标差异无统计学意义(P>0.05),治疗后2组患儿的TBi L、ALT及PT低于治疗前,ALB高于治疗前,且研究组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎能有效改善患儿的肝功能,疗效显著,具有临床推广价值。
Objective To observe the efficacy of adenosylmethionine combined with potassium and magnesium aspartate in the treatment of severe jaundice hepatitis in children. Methods 203 infants with severe jaundice hepatitis were randomly divided into study group 102 cases and control group 101 cases. The study group was treated with adenosylmethionine combined with potassium-magnesium aspartate and the control group with hepatocyte growth-promoting hormone combined with potassium-magnesium aspartate. The therapeutic effect and improvement of liver function in two groups were compared. Results After treatment, the total effective rate of the study group was 94.1%, which was significantly higher than that of the control group (83.2%) (P <0.05). There was no significant difference in the biochemical indexes of TBi L, ALT, PT, ALB between the two groups before treatment (P> 0.05). The TBiL, ALT and PT in the two groups were lower than those before treatment Before treatment, and the research group changed more than the control group, the differences were statistically significant (P <0.05). Conclusion Adenosine methionine combined with potassium and magnesium aspartate in children with severe jaundice hepatitis can effectively improve the liver function in children with significant curative effect and clinical value.