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霍乱弧菌O1群的临床感染可使患者获得免疫力而避免再发。但以往报道中,该自然保护的程度差异较大(0～>90%)。最近,在孟加拉国农村完成的口服灭活霍乱疫苗的系统前瞻性研究中,作者对自然感染的霍乱与其再发之间的相关性进行了分析。作者于1985～1988年对188153名居民进行监测,未发病者作为对照组,初发霍乱者列入接触组。根据随访的不同情况,分别记为发作、死亡、迁出和观察中止。霍乱初发和再发间的保护相关性以发病密度比(IDR)表示,该比率为接触组和对照组霍乱发病率相除而得。
The clinical infection of the Vibrio cholera O1 group allows the patient to gain immunity and avoid recurrence. However, in the past reports, the degree of natural conservation varied greatly (0 ~> 90%). In a recent systematic prospective study of oral inactivated cholera vaccines completed in rural Bangladesh, the authors analyzed the association between naturally-infected cholera and its recurrence. The author monitored 188,153 residents from 1985 to 1988, with no disease as a control group. Initial cases of cholera were included in the exposure group. According to the follow-up of different situations, were recorded as seizures, death, removal and observation suspended. The protective relativity between initial and recurrent cholera was expressed as the odds ratio (IDR), which is obtained by dividing the incidence of cholera in the contact and control groups.