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报道了 7例左房粘液瘤 (L AM组 )患者血浆抗凝血酶 (AT )的变化 ,并与 8例瓣膜置换术患者 (瓣膜置换术组 )及 8例健康献血员 (正常对照组 )检测结果进行了对比 ,结果表明 L AM组患者的 AT 含量明显低于瓣膜置换术组及正常对照组 (P<0 .0 5 )。 L AM组中有 4例出现肝素相对耐药现象 ,而瓣膜置换术组无 1例发生 ,差异亦有显著性 (P<0 .0 1)。因此 ,认为对左房粘液瘤患者进行体外循环心内直视手术时应密切观察及监测激活全血凝固时间(ACT)的变化及防止抗凝现象的发生
The changes of plasma antithrombin (AT) in 7 patients with left atrial myxoma (LAM group) were reported and compared with 8 patients with valve replacement (valve replacement group) and 8 healthy blood donors (normal control group) The test results were compared, the results showed that patients with L AM group AT content was significantly lower than the valve replacement group and the normal control group (P <0.05). In LAM group, 4 cases showed relative drug resistance of heparin, but no valve replacement occurred in 1 case, the difference was also significant (P <0.01). Therefore, patients with left atrial myxoma undergoing cardiopulmonary bypass undergoing open heart surgery should be closely monitored and monitored for changes in activated whole blood clotting time (ACT) and prevention of anticoagulation