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目的通过观察糖尿病微量白蛋白排泄率(UAER)的变化,探讨金水宝与缬沙坦联合治疗早期糖尿病肾病的疗效。方法161例患者按随机原则分为4组,实验组(金水宝与缬沙坦联合应用),金水宝组,缬沙坦组,洛汀新组,检测各组患者治疗前后的微量白蛋白排泄率(UAER),以评判治疗效果。结果经过16周治疗后,各组UAER治疗前与治疗后比较差异有统计学意义(P<0.01)。4组进行组间比较,实验组较其他3组UAER降低更为明显,差异有统计学意义(P<0.01),而对照组间两两比较,差异无统计学意义(P>0.05)。结论金水宝与缬沙坦联合治疗早期糖尿病肾病疗效显著。
Objective To observe the effect of Jinshuibao and valsartan in the treatment of early diabetic nephropathy by observing the changes of urinary albumin excretion rate (UAER). Methods 161 patients were randomly divided into 4 groups according to the principle of randomization. The experimental group (combined application of Jinshuibao and Valsartan), Jinshuibao group, Valsartan group and Lotensin group were used to detect the microalbumin excretion before and after treatment Rate (UAER) to judge the treatment effect. Results After 16 weeks of treatment, the difference of UAER before and after treatment in each group was statistically significant (P <0.01). 4 groups were compared between groups, experimental group than the other three groups UAER decreased more significantly, the difference was statistically significant (P <0.01), while the control group was no significant difference between any two groups (P> 0.05). Conclusion Jinshui Bao combined with valsartan in the treatment of early diabetic nephropathy significant effect.