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目的:研究经鼻间歇正压辅助通气(NIPPV)治疗早产儿呼吸窘迫综合征(NRDS)的疗效及安全性。方法:38例胎龄小于36周的NRDS病例随机分成两组,NIPPV组19例,经鼻持续正压辅助通气(NCPAP)组19例,记录分析两组病人的血气分析结果和转归情况、辅助通气时间及支气管肺发育不良(BPD)发生情况。结果:入院4小时复测血气PH值和PCO2NIPPV组较NCPAP组好转明显(P<0.05),因病情加重改用气管插管机械通气(MVET)的例数NIPPV组明显少于NCPAP组(P<0.05),好转病人平均辅助通气时间两组无明显差异,BPD发生情况两组无明显差异。结论:NRDS采用NIPPV治疗能有效减少MVET的使用比例。
Objective: To study the efficacy and safety of nasal intermittent positive pressure assisted ventilation (NIPPV) in the treatment of respiratory distress syndrome (NRDS) in preterm infants. Methods: Thirty-eight NRDS patients with gestational age less than 36 weeks were randomly divided into two groups: 19 cases in NIPPV group and 19 cases in NCPAP group. The blood gas analysis results and outcome of the two groups were recorded and analyzed. Assisted ventilation and bronchopulmonary dysplasia (BPD) occurred. Results: The blood PH value and PCO2NIPPV group were significantly better than those of NCPAP group (P <0.05) at 4 hours after admission. The number of MVET cases was significantly less than that of NCPAP group (P < 0.05). There was no significant difference between the two groups in the mean time of assisted ventilation in patients with improvement. There was no significant difference between the two groups in the incidence of BPD. Conclusion: NRDS treatment with NIPPV can effectively reduce the proportion of MVET.