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脑型疟疾可能是一种由恶性疟原虫感染引起的急性弥散性脑病。诊断困难,死亡率高达33％,尽管对本病进行了广泛地实验研究,然而在其病理生理和治疗方面尚未取得完全一致的意见。Toro等近来复习并总结了19例脑型疟疾死亡病例的临床和病理学特征,并对脑型疟疾的发病机制中的神经变态反应方面的影响及治疗学有关问题作了阐明。 19例脑型疟疾死亡病例进行了完全的尸检,并进行了充分的神经病理学的检查。其中肉眼检查有脑水肿16例(84％),有血管充血,主要在白质的点
Cerebral malaria may be an acute diffuse encephalopathy caused by Plasmodium falciparum infection. Diagnosis is difficult with a mortality rate of up to 33%. Although extensive experimental studies have been conducted on this disease, no exact agreement has been reached on its pathophysiology and treatment. Toro et al recently reviewed and summarized the clinical and pathological features of 19 deaths from cerebral malaria and clarified the effects of neuro-allergic reactions in the pathogenesis of cerebral malaria and related issues of therapeutics. Nineteen dead cases of cerebral malaria were completely autopsy-tested and fully neuropathologically examined. Macroscopic examination of which 16 cases of brain edema (84%), vascular congestion, mainly in the white matter point