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目的:探讨危重新生儿甲状腺功能的变化情况。方法:选取广东省佛山市三水区妇幼保健院2012年4月-2014年4月期间接收的接收的60例危重新生儿作为本次研究的观察组,同时选取60例同期出生的正常新生儿作为对照组,两组研究对象均在第3~7天进行甲状腺功能检测,并对其检测结果进行对比分析。结果:观察组患儿血清总三碘甲状腺原氨酸(T3)、甲状腺素血清总甲状腺素(T4)、游离三碘甲状腺氨酸(FT3)、游离四碘甲状腺氨酸(FT4)水平均明显低于对照组,组间比较,差异具有统计学意义(P<0.05);观察组患儿反三碘甲状腺原氨酸(r T3)明显高于对照组,组间比较,差异具有统计学意义(P<0.05);两组患儿比较促甲状腺激素(TSH)比较,差异无统计学意义(P>0.05);恢复期观察组患儿T3、T4、FT3、FT4、r T3均基本恢复正常,于治疗前比较,组间比较,差异具有统计学意义(P<0.05);TSH治疗前后比较,差异无统计学意义(P>0.05)。结论:危重症新生儿甲状腺功能伴有严重损害现象,疾病恢复后其甲状腺功能可自行恢复,因而无需给予患儿甲状腺素治疗。
Objective: To investigate the changes of thyroid function in critically ill neonates. Methods: Sixty critically ill newborns received during the period from April 2012 to April 2014 in Sanshui District Maternal and Child Health Hospital of Foshan City, Guangdong Province were selected as the observation group and 60 normal newborns As a control group, the two groups of subjects were in the first 3 to 7 days for thyroid function testing, and test results were compared. Results: The levels of serum total triiodothyronine (T3), thyroxine serum total thyroxine (T4), free triiodothyronine (FT3) and free tetraiodothyronine (FT4) in the observation group were all significantly higher Lower than the control group, the difference between the two groups was statistically significant (P <0.05); children in the observation group anti-triiodothyronine (r T3) was significantly higher than the control group, the difference between the two groups was statistically significant (P <0.05). There was no significant difference in thyrotropin (TSH) between the two groups (P> 0.05). T3, T4, FT3, FT4 and r T3 in observation group recovered to normal (P <0.05). There was no significant difference between the two groups before and after TSH treatment (P> 0.05). Conclusion: Thyroid function in critically ill neonates is associated with severe damage. After thyroid function is restored, the thyroid function can be restored by itself, so there is no need to give thyroid hormone treatment in children.