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目的探讨研究2型糖尿病周围神经病变的影响因素。方法选取126例2型糖尿病患者,其中82例2型糖尿病合并周围神经病变患者作为观察组,44例2型糖尿病非合并周围神经病变患者作为对照组,对两组患者各项临床指标进行检查和比较,分析2型糖尿病周围神经病变的影响因素。结果两组患者的年龄、体质量指数、收缩压、舒张压、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(Ins)指标比较差异无统计学意义(P>0.05)。观察组患者病程显著长于对照组,空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、尿微量白蛋白肌酐比值(ACR)、C反应蛋白(CRP)和同型半胱氨酸(Hcy)水平显著高于对照组,2 h胰岛素(2 h Ins)显著低于对照组,差异均具有统计学意义(t=7.78、3.65、7.44、5.13、9.38、12.59、20.91、13.88,P<0.05)。结论 2型糖尿病合并周围神经病变的主要影响因素为糖尿病病程、糖化血红蛋白、尿微量白蛋白肌酐比值、C反应蛋白、同型半胱氨酸等,临床上需要加强预防和控制。
Objective To investigate the influencing factors of peripheral neuropathy in type 2 diabetic patients. Methods A total of 126 patients with type 2 diabetes mellitus were selected. Among them, 82 patients with type 2 diabetes mellitus complicated with peripheral neuropathy were selected as the observation group and 44 patients with type 2 diabetes mellitus without peripheral neuropathy were selected as control group. Compare and analyze the influencing factors of type 2 diabetic peripheral neuropathy. Results The age, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol ), There was no significant difference in fasting insulin (P> 0.05). The course of the observation group was significantly longer than that of the control group. The fasting blood glucose (FBG), 2 h PG, Hb A1c, ACR, CRP and The level of homocysteine (Hcy) was significantly higher than that of the control group, while the level of 2 h insulin was significantly lower than that of the control group (t = 7.78,3.65,7.44,5.13,9.38,12.59, 20.91, 13.88, P <0.05). Conclusion The main influencing factors of type 2 diabetes complicated with peripheral neuropathy are diabetes course, glycosylated hemoglobin, urinary albumin creatinine ratio, C-reactive protein and homocysteine, so the prevention and control should be strengthened clinically.