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目的:探讨KAI-1基因在胃癌组织中的表达和临床意义,以及与病理类型的联系。方法:选取2008年3月—2011年3月行手术治疗的胃癌患者40例和同期手术治疗的非胃癌疾病患者20例的胃石蜡标本,采用免疫组织化学染色SABC法检测癌组织及胃良性病变组织中的KAI-1基因的表达。结果:KAI-1基因在胃癌组织中的表达阳性率明显低于胃良性病变组织(P<0.05)。且这种表达差异体现在不同的胃癌组织类型中。结论:KAI-1基因的低表达可能是导致肿瘤侵袭力增强和易发生转移的危险因素之一。
Objective: To investigate the expression and clinical significance of KAI-1 gene in gastric cancer and its relationship with pathological types. Methods: Forty gastric cancer patients who underwent surgical treatment from March 2008 to March 2011 and 20 gastric cancer patients who underwent surgical treatment during the same period were enrolled in this study. The immunohistochemical staining SABC method was used to detect the cancerous tissues and gastric benign lesions KAI-1 gene expression in tissues. Results: The positive rate of KAI-1 gene expression in gastric cancer tissues was significantly lower than that in gastric benign lesions (P <0.05). And this expression difference is reflected in different types of gastric cancer. Conclusion: The low expression of KAI-1 gene may be one of the risk factors that lead to invasiveness and metastasis.