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采用ＳＭＡＯ休克模型观察大气小肠单纯缺血１ｈ（Ｉ组），缺血ｌｈ后再灌１ｈ（Ｉ／Ｒ组）及假手术组（Ｓｈａｍ组）的血浆及肠组织内皮素－１（ＥＴ－１）的变化。结果表明，Ｉ组血浆ＥＴ－１与Ｓｈａｍ组比较无显著增高（Ｐ＞０．０５），而肠组织ＥＴ－１则显著憎高（Ｐ＜０．０１），肠组织损伤明显；１／Ｒ组血浆及肠组织ＥＴ－１均显著高于其它两组（Ｐ＜０．０１），肠组织严重损伤。提示ＥＴ－１是肠缺血－再灌损伤的重要因素。
SMAO shock model was used to observe the changes of plasma and intestinal endothelin-1 (ET-1) in I / R group (I group), Ih group (I / R group) and sham operation group (Sham group) )The change. The results showed that there was no significant increase in plasma ET-1 compared with Sham group (P> 0.05), while ET-1 in intestinal tissue was significantly hated (P <0.01) ET-1 in plasma and intestinal tissue were significantly higher than the other two groups (P <0.01), and the intestinal tissue was severely damaged. Tip ET-1 is an important factor in intestinal ischemia-reperfusion injury.