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目的分析原发性干燥综合征(primary Sjgren’s syndrome,PSS)合并周围神经病变患者的血清免疫学改变。方法选择2011—2014年本院收治的PSS患者86例,依据患者是否伴有周围神经病变分为2组,观察组25例:合并周围神经病变;对照组61例:单纯PSS。分析两组患者血清免疫学指标。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果原发性干燥综合征累及周围神经的比例为29.1%(25/86)。观察组血清TNF-α水平为(31.91±7.73)μg/L,显著高于对照组的(25.26±5.32)μg/L,差异有统计学意义(t=4.586,P<0.05)。观察组患者为20.0%(5/25)显著高于对照组的1.6%(1/61),差异有统计学意义(P<0.05)。结论PSS患者有一定比例累及周围神经,合并周围神经病变的患者血清TNF-α水平及SSA、SSB双阳性比例增高。
Objective To analyze the serum immunological changes in patients with primary Sjögren’s syndrome (PSS) complicated with peripheral neuropathy. Methods Totally 86 PSS patients admitted to our hospital from 2011 to 2014 were divided into two groups according to whether the patients had peripheral neuropathy or not. The observation group consisted of 25 patients with peripheral neuropathy. The control group consisted of 61 patients with simple PSS. Serum immunological parameters of two groups were analyzed. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The rate of peripheral nerve involvement in primary Sjogren’s syndrome was 29.1% (25/86). The serum level of TNF-α in the observation group was (31.91 ± 7.73) μg / L, which was significantly higher than that in the control group (25.26 ± 5.32) μg / L, the difference was statistically significant (t = 4.586, P <0.05). The observation group was 20.0% (5/25) was significantly higher than the control group of 1.6% (1/61), the difference was statistically significant (P <0.05). Conclusions There is a certain proportion of PSS patients with peripheral nerves, peripheral neuropathy patients with serum TNF-α levels and SSA, SSB double positive ratio increased.